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What Products Contain GHK?

We are frequently asked about which products contain GHK (1st generation copper peptides). Ten of our products have GHK. 3% GHK VIP Luxury Cream or 3% VIP Luxury Serum has 3% GHK. Super GHK Copper (Cream or Serum) has 1%. Those four products do not have 2nd generation copper peptides.

The remaining 6 products have both 1st and 2nd generation copper peptides so you are getting the best of both worlds. The products are Perfect Lift Decolletage Cream (0.3%), Skin Signals Cream or Solution (0.3%), Copper Sun Tanning & Firming Lotion (.05%), and Hair Signals Cream or Solution (.02%)

Does Copper from Copper Peptide Products Enter the Bloodstream?

Very little copper from copper peptide skin products penetrates through the skin (and even still are able to effect beautiful cosmetic results).
Tests of copper peptide products have found that only about 0.1% or less of the copper passes through the skin. In contrast, fatty molecules penetrate the skin much more easily.

In summary, normal use of a copper peptide products might possibly result in a very small uptake of copper. For example, if one used 2 grams of product daily that contained 2 milligrams of copper, and if the skin uptake was at 0.1% penetration, this would introduce about 0.002 milligrams of copper into your body. If penetration through the skin was as high as 1%, your body uptake would still be about 0.02 milligrams or only 1% of the RDA for copper."

How Long Does It Take to See Results?
Each individual's skin is different and unique and much will depend on the existing condition of the skin and your own skin care goals.
Generally, we recommend to use the products for at least 4-6 weeks. It is typically within that amount of time most clients report seeing the beginnings of positive changes in their skin. Better results always come with time.

What Is the Difference Between Folligen and Hair Signals?

Both products contain the same concentration of copper peptides. One is not stronger than another.
The difference between Folligen and Hair Signals is that Hair Signals is further enhanced by natural DHT agents and added penetrating agents.
Hair Signals Cream contains tea extracts, pygeum africanum, and the addition of both penetrating agents Polysorbate-20 and Polysorbate-80. In contrast, Folligen Cream does not contain the added ingredients and only contains one penetrating agent: Polysorbate-80.

Hair Signals Solution contains the addition of tea extracts and pygeum africanum. Whereas, Folligen Solution does not.

Hair Signals (both the cream and the solution) also contains GHK (1st generation) as noted above. Unfortunately the raw product of GHK is costing more, and we expect that Hair Signals price will indeed rise in the near future.

What Is the Difference Between Our Emu Oil-S for Skin and Emu Oil-S for Hair? What does the “S” stand for?

The only difference between Emu Oil-S for Skin and Emu Oil-S for Hair is that the one for Hair has saw palmetto oil added due to its excellent benefits for scalp skin.

The "S" in Emu Oil-S Lipid Replenisher for Skin and Emu Oil-S Lipid Replenisher for Hair, stands for “Supplemented”. That is why “S” is in the name for both. Both products are supplemented with an exclusive mix of anti-oxidants and vitamins that Dr. Pickart adds in.

Emu Oil-S for Skin can be used on both facial, body, and scalp skin. But using Emu Oil-S for Hair on the face may cause breakouts (not increased facial hair).

Are Skin Biology Products Gluten-Free?

Yes. None of our skin care products contain gluten. But if you have any sensitivities to topical cosmetic products, we recommend to carefully review our page listing all product ingredients at: www.reverseskinaging.com/ingredients1.html.

Discuss the ingredients with your physician or dermatologist - If you have any further concerns or inquiries, feel free to contact Dr. Pickart directly at: drpickartchat@skinbiology.com.



What Is the Difference Between GHK (1st Generation Products) and 2nd Generation Products?

Brief Summary: “First Generation Products” are based on Dr. Pickart's original discovery of GHK-Cu which stands for glycyl-histidyl-lysine. GHK has been shown to produce a number of amazing benefits on the skin. However, it is fragile and breaks down very easily. So Dr. Pickart found that combining small copper and soy-based peptides (“Second Generation Products”) could produce the same effect and also be a viable product for fading the appearance of blemishes and the more “difficult to affect” cosmetic signs of aging.

Why the Price Difference: The answer has to do with the fact that the raw material for manufacturing GHK-Copper is quite expensive. GHK-Cu has had the bulk of cosmetic and glycyl-histidyl-lysine copper (II)general studies performed on it. Due to its very positive findings and years in existence, the price of the raw product reflects the decades of work that have gone into developing this cosmetic ingredient.

Which “Generation” is Stronger/Better? "Stronger" might not be the best description - "Better suited for certain skin rejuvenation tasks" might be a more appropriate phrase. Although GHK has a number of properties that it seems science is continuing to appreciate, GHK is very fragile. Second Generation Copper-Peptides are more breakdown resistant and adhere better to the skin. So the type of rejuvenation needed and the client's skin type and goals will dictate which is better for that particular individual. Remember, "stronger" doesn't necessarily mean better / Some client's skin may actually do better using the milder 1st generation products in certain areas or if they are new to copper-peptides.

Long Explanation:
“The first generation products, built around GHK-Cu, have performed well for cosmetic skin rejuvenation. But they were not a significant commercial success and have not ignited strong customer demand. Thus, it was necessary to use the insights from GHK-Cu to develop an improved type, along with improved methods of administration (such as concomitant treatments with hydroxy acids, retinoic acid, natural skin oils, and various abrasive procedures) to develop commercially successful products.

GHK-Cu does work on skin to reduce the appearance of wrinkles, fine lines, and photodamage while improving skin glow.

Dr. Pickart wrote patent applications on these cosmetic actions of GHK-Cu in 1989 but these discoveries gathered dust for a decade. (Pickart L, US patents 5,135,913 Skin treatment compositions comprises GHL-Cu / 5,348,943 Cosmetic and skin treatment compositions)

Finally, between 1998 and 2002, more extensive human observations from around the world poured in solidifying Dr. Pickart's work.

The problem was that GHK-Cu is fragile and breaks down in a short time. It also is unstable when used with hydroxy acids. So in 1995, Dr. Pickart started searching for a more stable form of SRCPs. Since GHK-Cu has a very strong affinity to bind copper (II) ions, it occurred to Dr. Pickart that other small peptides might do the same if pre-loaded with copper ions.

Therefore, in 1994 Skin Biology was started to develop improved second-generation skin rejuvenating copper peptides (SRCPs) with enhanced potency, breakdown resistance, and high adherence to skin.

To accomplish this goal, Dr. Pickart isolated peptide fragments from soy protein digests that possessed the desired qualities when chelated to copper (II). Such peptides have a long history of safe use in cosmetic products.

Howard Maibach of the University of California San Francisco and colleagues also tested the second-generation copper peptides in four small placebo-controlled studies. They found that creams made from the new copper complexes were safe and produced significant results.

Excitingly, the breakdown-resistant SRCPs can be used with hydroxy acids and retinoic acid to enhance skin rejuvenation and the fading of blemishes. We will continue to develop and improve this 2nd generation approach to SRCPs to eventually produce commercially viable products.”