I have never stored Super Cox 2X in the refrigerator but now see it posted to do so. Did I lose any of it's effectiveness..

No, it will actually last longer. But copper peptide crystals may form in the cold refrigerator.

But at room temperature, it tends to form a black color on the surface. It is still OK but looks a little strange.

It is a difficult product to formulate without detergents that would damage the skin barrier.