sometimes it is extremely challenging for the vast majority of endocronologist to correctly diagnose a disease due to complexity of such aillment. I have been suffering since early childhood with familial phaeochromocytoma normotensive no high blood pressure only slightly elevated noradrenalin and much higher level of dopamine so i am not a good candidate for alpha blocker, but my heart rate at rest is quite high with palpitaion and excessive nocturnal acth level and high daily free urine cortisol.

My question is can Dhea reduce cortisol in my case which is not from stress rather from metabolic stress and second,can hyperactive sympathetic nervous system leads to low iron level due to inflammatory IL-6 production.Third, dopamine is vasodilator and diuretic Doesn't it dehydrates the skin,can copper peptides counteract this negative action of dopamine in term of increasing water holding substances like glycosaminoglycans and proteoglycans.
I take daily vitamin c 1000 gram , copper glycinate 6 mg and 18 mg iron tablets , but serum iron and mcv are still low although i eat balanced food with meat ,poultry and fish and lots of green vegetables and fruits

This message has been edited. Last edited by: amirpana,

This is a complicated disease and only a endocrinologist can give you a good answer.

As for the DHEA, look up on Google "familial pheochromocytoma normotensive dhea". It does appear that DHEA-sulfate is low in this condition.

Does diurisis due to the catecholamine Dopamine has an effect on skin thickness and oiliness.And can the skin revert to the healthy condition by increasing the extracellular matrix with copper peptides(SRCP) and more water retension in the skin,thus increasing overall skin volume.

The SRCPs have a very broad range of positive actions from the stem cell level on up.

Interesting, GHK-Cu lowers blood pressure and also binds to angiotensin II which increases blood pressure. So maybe the GHK-Copper would be the best to try.


From Wikipedia

The kidney normally produces up to 180 L of "pro-urine" (glomerular filtrate) per day, but reabsorbs most of this before entering the calyx of the kidney. No more reabsorption takes place past this point.

Polyuria is increased diuresis. This may be due to large fluid intake, various illnesses (diabetes insipidus, osmotic diuresis due to diabetes mellitus or hypercalcemia) or various chemical substances (diuretics, caffeine, alcohol). It may also occur after supraventricular tachycardias, during an onset of atrial fibrillation, childbirth, and the removal of an obstruction within the urinary tract. Diuresis is restrained by antidiuretics such as ADH, angiotensin II and aldosterone.

Cold diuresis is the occurrence of increased urine production on exposure to cold, which also partially explains immersion diuresis.

Substances that increase diuresis are called diuretics.