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Location: southerm md
Registered: 19 October 2008
Posts: 28
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Make Up Artists Choice has two new products that have mandelic acid in them. I was interested in purchasing them and remembered it was on the not recommended list. Under the product detail, it says that mandelic acid is derived from bitter almonds. I was just wondering if you would check these products out and tell me your opinion.

MUAC Radiance Peel
Pore Minimizer With Sepicontrol A5

Thank You
Dawn

This message has been edited. Last edited by: SkinBiologyWebmaster,
Picture of Dr. Pickart
Location: Skin Biology
Registered: 15 September 2004
Posts: 7065
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Mandelic acid is an artificial acid and is patented for various skin are uses. It also is neurotoxic and can induce adverse effects on the peripheral nervous system and produce toxic peripheral neuropathy at very low levels.

Material Safety Data Sheet

S-(+)-Mandelic acid MSDS Section

1: Chemical Product and Company Identification Product

Name: S-(+)-Mandelic acid

Information:Sciencelab.com,

Effects:Hazardous in case of ingestion. Slightly hazardous in case of skin contact (irritant, permeator), of eye contact(irritant), of inhalation.

Potential Chronic Health Effects:CARCINOGENIC EFFECTS: Not available.MUTAGENIC EFFECTS: Not available.TERATOGENIC EFFECTS: Not available.DEVELOPMENTAL TOXICITY: Not available.The substance is toxic to mucous membranes.Repeated or prolonged exposure to the substance can produce target organs damage.

Skin Contact:After contact with skin, wash immediately with plenty of water. Gently and thoroughly wash the contaminated skinwith running water and non-abrasive soap. Be particularly careful to clean folds, crevices, creases and groin.Cold water may be used. Cover the irritated skin with an emollient. If irritation persists, seek medical attention.Wash contaminated clothing before reusing.

Serious Skin Contact: Allow the victim to rest in a well ventilated area. Seek immediate medical attention.

Chronic Effects on Humans: The substance is toxic to mucous membranes.Other Toxic Effects on Humans:Hazardous in case of ingestion. Slightly hazardous in case of skin contact (irritant, permeator), of inhalation.

..............................

from http://www.chemcas.com/msds/cas/msds75/8015-54-1.asp

* ACUTE TOXICITY DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose


from http://www.chemcas.com/msds/cas/msds75/8015-54-1.asp

* ACUTE TOXICITY DATA **

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Human
DOSE/DURATION : 40 ug/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - visual field changes
Behavioral - hallucinations, distorted perceptions
Gastrointestinal - nausea or vomiting
REFERENCE :
JNMDAN Journal of Nervous and Mental Disease. (Williams & Wilkins Co., 428
E. Preston St., Baltimore, MD 21202) V.3- 1876- Volume(issue)/page/year:
131,428,1960

.....................
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intramuscular
SPECIES OBSERVED : Human - man
DOSE/DURATION : 150 ug/kg
TOXIC EFFECTS :
Behavioral - hallucinations, distorted perceptions
REFERENCE :
FEPRA7 Federation Proceedings, Federation of American Societies for
Experimental Biology. (Bethesda, MD) V.1-46, 1942-87.
Volume(issue)/page/year: 32,250,1973

TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intramuscular
SPECIES OBSERVED : Human
DOSE/DURATION : 100 ug/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation)
Behavioral - hallucinations, distorted perceptions
REFERENCE :
85IVAW "Possible Long-Term Health Effects of Short-Term Exposure to Chemical
Agents," National Research Council, 3 vols., Washington, DC, National
Academy Press, 1982-85 Volume(issue)/page/year: 1,L1,1982

Neurophysiological Changes in Rats
Subchronically Treated with Styrene or Its Metabolite, Junichi M,
Megumi N, Wenyuan Z, Kazuo A, J Occup Health 2000; 42: 328–335. It is
also being tested as a sperm inactivator and preservative.

We do not recommend its use.
Location: Canada
Registered: 02 January 2012
Posts: 52
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Dr Pickart,
I just found this old thread about Mandelic Acid and wondered if this is the same 'acid' as that sold by Platinum Skincare ? they have a Mandelic Peel that I have just started using?

Thanks !
Caelum
Picture of Skin Biology
Location: Skin Biology in Bellevue, Washington - USA
Registered: 22 June 2004
Posts: 4865
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Dear caelum:

Yes, this is the same acid: Mandelic Acid (it is carried in many cosmetic stores/spas).

Dr. Pickart believes their are better hydroxy acids that are gentler (and just as effective) that can be easily substituted.

Best Wishes,
-Skin Biology
Location: Canada
Registered: 02 January 2012
Posts: 52
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Ohhh
I just started using their Madelic Peel.

I do have Dr Pickart's Exfol, etc.. and was just looking at their peels as i remembered Dr Pickart recommended them at some point.
Unless I"m wrong?

Can you recommend other hydroxy acids that are just as effective that he has or others?

Thank you!
Caelum Smiler
Picture of Skin Biology
Location: Skin Biology in Bellevue, Washington - USA
Registered: 22 June 2004
Posts: 4865
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Dear caelum:

We have recommended that company before to those searching for effective at-home peels. But we've always recommended either their lactic, glycolic, or salicylic acids. Those are the types that you will generally want to look for.

Lactic acid is one of the safest skin exfoliating hydroxy acids. It is naturally present in human skin and so is very safe in contrast to many unnatural hydroxy acids sold for use in skin care.

Lactic acid is an AHA (alpha hydroxy acid) the synthetic base of which comes from milk. It usually takes about eight weeks of regular use to see a significant improvement in the skin, but even at peel percentages of 40%, clients find that it is effective without being excessively irritating.

Many clients find using a 40% lactic acid once a month (or every 2 weeks) is an effective way to reach certain skin care goals (such as fading marks, blemishes, nasolabial lines, sun damage, etc) --- The days they do not apply their peels, you can use a light amount of LacSal Cream (10% leave-on, mild exfoliant) for everyday rejuvenation.

Best Wishes,
-Skin Biology
Location: Canada
Registered: 02 January 2012
Posts: 52
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Thank you SkinBiology,
I guess it's best I forget the Mandelic peel I have here, Would it be safe enough to finish the bottle? Or start with a Lactic Acid one at 40%?
Why doesn't Dr Pickart have those higher % peels? It would be nice to just get it from him (I wouldn't have made this mistake!) Wink
I'm still working on sun damage and just trying to keep up with my aging skin at 46..I seem to have a heavier skin with larger pores, and lines that just really want to spread especially around my eyes. Deep heavy wrinkling is just waiting to spread it seems. Almost seems like a losing battle no matter what I do.If not for my eyes, I would be okay with the rest of my face.
Any suggestions or is it just inevitable?
Thank you,
Caelum Smiler
Picture of Dr. Pickart
Location: Skin Biology
Registered: 15 September 2004
Posts: 7065
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I would not use a neurotoxin like mandelic acid.
Location: Canada
Registered: 02 January 2012
Posts: 52
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Hmm okay off it goes to the garbage dump then.

Thank you!
Caelum
Picture of Dr. Pickart
Location: Skin Biology
Registered: 15 September 2004
Posts: 7065
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The right choice!
Location: Canada
Registered: 02 January 2012
Posts: 52
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Smiler always appreciate your research! Smiler
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