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Location: US
Registered: 05 May 2009
Posts: 11
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Its the only thing that calms these little red bumps (forget what derm called it) while on accutane- im just going into my last month. But now i hear it can damage your skin, and my skin is already so so damaged Frowner. Should i not use it at all, or just very occasionally? If it thins my skin, will it go back to normal after a while of not using it?

Does the skin on any part of your body that has had cortisone cream applied to in the past return to normal eventually, or is it permanently damaged?
Picture of Dr. Pickart
Location: Skin Biology
Registered: 15 September 2004
Posts: 4540
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Try using a GHK-copper Serum to control the irritation. GHK-Cu has huge anti-inflammatory and repair actions.

The human peptide GHK is generated from the extracellular matrix during tissue breakdown and activates remodeling processes that restore the normal tissue morphology. Published results on GHK actions are defining the biochemical processes of remodeling. Based on published studies of, we know:

1. GHK is generated during tissue breakdown. As it is generated it binds copper and lowers cellular copper. This increases stem cell proliferation. It also helps induce an inflammatory condition that kills bacteria and helps remove damaged tissue.

GHK also attracts macrophages which clean up cellular damage, capillary cells which build blood vessels,a nd mast cells which help tighten skin.

2. As copper builds up the the affected region, GHK is converted to GHK-Cu which pushes stem cell into the types of differentiated cells needed by the organs. GHK-CU also increase P63, a protein needed for epithelial stem cell function. Without P63, skin rapidly ages.

3. The GHK-Cu stops the inflammatory condition by increasing the antioxidant proteins superoxide dismuate and decorin and vascular vasodilation. It suppresses damage by oxygen radicals and reactive carbonyl species, thromboxane formation, the release of oxidizing iron, TGF-beta-1, TNF-alpha, and protein glycation. It blocks ultraviolet damage to skin keratinocytes and improves fibroblast recovery after X-ray treatments.

4. GHK-Cu increased synthesis of collagen, elastin, metalloproteinases, anti-proteases, vascular endothelial growth factor, FGF-2, NGF, neutrotropins 3 and 4, and erythropoietin.

5. It increases the proliferation of healing cells (fibroblasts, keratinocytes, chrondrocytes, osteoblasts). It increases nerve outgrowth, angiogenesis, and hair follicle size.

6. GHK-Cu stimulates healing in numerous models and in humans. On aged humans, it tightens skin, improves elasticity and firmness, reduces fine lines, wrinkles, photodamage, and hyperpigmentation. It also improves hair transplant success, protects hepatic tissue from tetrachloromethane poisoning, blocks stomach ulcer development, heals intestinal ulcers and bone tissue.

7. Both GHK and GHK-Cu strongly increase infection resistance.
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