Skin Bio/Dr. Pickart,

Will the new DMAE soon be available?

Kathy

Dear KathyC:

Dr. Pickart will probably post on this tomorrow, but thanks for your inquiry.

We hope to have that for you to sample real soon. We'll announce it here first.

Best Wishes,
-Skin Bio Team

Thanks. I've been anxiously awaiting this product and have held off on buying any other brand! I'm excited to hear what type he decided to make and to try it.

Kathy

We hope that in about three weeks we will be able to give our clients two versions of a DMAE product to test.

We tried several formulations that did not work well and had to go back to square one.

Yay! I'm sure it will be worth the wait.

I should have read everything before I replied to DMAE question in Wrinkle Reduction discussion. If I had known about this, I would have told thegoodwitch to just wait until the Pickart DMAE is out!

What does DMAE do for the skin and is it available yet?

DMAE offers a temporary lifting or firming effect to some people, although some do not see any such results from using it at all. There is also evidence that there is a cumulative effect from using it regularly and in clinical trials it showed improvement after 16 weeks. The trials went on for 52 weeks with continuous improvement.

"The role of dimethylaminoethanol in cosmetic dermatology.
Am J Clin Dermatol. 2005;6(1):39-47. Grossman R.
Johnson and Johnson Consumer Products Worldwide, Skillman, NJ 08558

Skincare formulations for the improvement of aging skin are increasingly important consumer products. Here, we review available data on one such agent - 2-dimethylaminoethanol ( DMAE ) or deanol - that has recently been evaluated in a placebo-controlled trial. DMAE is an analog of the B vitamin choline and is a precursor of acetylcholine. Although the role of acetylcholine as a neurotransmitter is well known, growing evidence points to acetylcholine as a ubiquitous cytokine-like molecule that regulates basic cellular processes such as proliferation, differentiation, locomotion, and secretion in a paracrine and autocrine fashion. Indeed, this modulatory role may contribute to the cutaneous activity of DMAE. In a randomized clinical study, 3% DMAE facial gel applied daily for 16 weeks has been shown to be safe and efficacious in the mitigation of forehead lines and periorbital fine wrinkles, and in improving lip shape and fullness and the overall appearance of aging skin. These effects did not regress during a 2-week cessation of application. Beneficial trends (p > 0.05 but The acute skin-firming effects of DMAE have been confirmed by quantitative measures of cutaneous tensile strength. In vitro studies in peripheral blood lymphocytes indicate that DMAE is a moderately active anti-inflammatory agent. Although its mechanisms of action in the skin remain to be elucidated, evidence suggests that the skin is an active site of acetylcholine synthesis, storage, secretion, metabolism, and receptivity. Muscarinic acetylcholine receptors have been localized to keratinocytes, melanocytes and dermal fibroblasts, whereas nicotinic acetylcholine receptors have been found in keratinocytes. The role of acetylcholine and the role of DMAE as a modulator of acetylcholine-mediated functions in the skin remain to be elucidated.Conclusions: Thus, the benefits of DMAE in dermatology include a potential anti-inflammatory effect and a documented increase in skin firmness with possible improvement in underlying facial muscle tone. Studies are needed to evaluate the relative efficacy of DMAE compared with other skin-care regimens (e.g., topical antioxidant creams, alpha-hydroxy acids).

Split face study on the cutaneous tensile effect of 2-dimethylaminoethanol (dmae) gel.
Skin Res Technol 2002 Aug;8(3):164-7
Beyond subjective assessments, the effect of skin tensors is difficult to assess. The present 2-phase randomized double-blind split face study was designed to compare the effect of a gel containing 3% 2-dimethylaminoethanol (deanol, DMAE) with the same formulation without DMAE. METHODS: In a first pilot study, sensorial assessments and measures of the skin distension under suction were performed in eight volunteers. In a second study conducted in 30 volunteers, shear wave propagation was measured. RESULTS: Large interindividual variations precluded any significant finding in the first study. The DMAE formulation showed, however, a significant effect characterized by increased shear wave velocity in the direction where the mechanical anisotropy of skin showed looseness. CONCLUSION: The DMAE formulation under investigation increased skin firmness."

quote:

Originally posted by Siân:
What does DMAE do for the skin and is it available yet?

We have the lab making two more versions of DMAE. When they are ready, we will give the versions away with orders. We should have them by December 1.

Great. Thanks KathyC and Dr. Pickart. I think I didn't quite get half of your post, KathyC, but I got the drift. (Obviously no science major. History is my thing!)

I'll be taking advantage of the samples when they come out. How would I use the product in relation to my other products (say my cleanser, LacSal (or Exfol), CP serum, and Emu OilS. Oh, yes, and Day Cover

If Dr. Pickart has made a water based product, and I hope he has, and if you are using CPs, I would apply it this way:

Cleanse
CP Serum
DMAE (there may be a 10 min wait time recommended)
BHO

If you are using LacSal, apply it before the DMAE product.

Kathy

We are still working on our latest DMAE formula but have a slowdown. We sent a bottle of DMAE to the manufacturing lab - about 50 miles north of our office by ground transportation.

This message has been edited. Last edited by: Dr. Pickart,

If anyone wants DMAE now, I think I have found one that might be "worthy". I will be trying it out and will report back.

http://www.psfskincare.com/dmae_gel.htm

Kathy

quote:

So, now, with the delay, when can we expect the DMAE product? I'm holding off on an order b/c of the impending DMAE, but I desperately need to get some stuff for the holidays (both to look good myself AND for presents).

We ordered more DMAE already. So I hope we have it in early December.

We should have it in early December and will give it away with orders for a time.

This message has been edited. Last edited by: Dr. Pickart,

quote:

Originally posted by KathyC:
If anyone wants DMAE now, I think I have found one that might be "worthy". I will be trying it out and will report back.

http://www.psfskincare.com/dmae_gel.htm

Kathy

Hi Kathy. I recently ordered this DMAE, too. I've only been using it for about a week, but I have to say that I like it much better than the others that I've tried (Reviva, IN).

The glycerin in Reviva made my skin look shiny and I found the liquid IN annoying to apply.

The PSF product is a nice gel-like texture and feels very soothing when applied.

Have you tried it yet?

quote:

Originally posted by Dr. Pickart:
We are still working on our latest DMAE formula but have a slowdown. We sent a bottle of DMAE to the manufacturing lab - about 50 miles north of our office by ground transportation.

Dr Pickart, what ingredients did you use in your DMAE formulation?

quote:

Originally posted by Jackie:

quote:

Originally posted by KathyC:
If anyone wants DMAE now, I think I have found one that might be "worthy". I will be trying it out and will report back.

http://www.psfskincare.com/dmae_gel.htm

Kathy

Hi Kathy. I recently ordered this DMAE, too. I've only been using it for about a week, but I have to say that I like it much better than the others that I've tried (Reviva, IN).

The glycerin in Reviva made my skin look shiny and I found the liquid IN annoying to apply.

The PSF product is a nice gel-like texture and feels very soothing when applied.

Have you tried it yet?

Hi Jackie! I just received it last Friday. I have only applied it 3 or 4 times now, and I do like it. It is guaranteed 3% amine DMAE, and I also like the gel-like texture. I'm still trying it out though, and would like to get through a couple of bottles before I give my final opinion. I remember buying IN's DMAE and finding a great effect in one batch and the next batch was a dud, so I want to give this a fair test.

It is alkaline, so I am applying it to clean skin and waiting 30 minutes before applying anything else to get the best bang for my buck! Where are you putting it in your routine?

Kathy

quote:

Originally posted by Jackie:

quote:

Originally posted by Dr. Pickart:
We are still working on our latest DMAE formula but have a slowdown. We sent a bottle of DMAE to the manufacturing lab - about 50 miles north of our office by ground transportation but UPS dropped it and we are waiting for more DMAE.

Dr Pickart, what ingredients did you use in your DMAE formulation?

It will be a little like CP Serum but with the SRCPs replaced with DMAE.

quote:

Originally posted by Dr. Pickart:

quote:

Originally posted by Jackie:

quote:

Originally posted by Dr. Pickart:
We are still working on our latest DMAE formula but have a slowdown. We sent a bottle of DMAE to the manufacturing lab - about 50 miles north of our office by ground transportation but UPS dropped it and we are waiting for more DMAE.

Dr Pickart, what ingredients did you use in your DMAE formulation?

It will be a little like CP Serum but with the SRCPs replaced with DMAE.

It will be water based serum and not a gel formula then? Can you tell us, Dr. Pickart, what the pH will be? It would make a difference as far as the order of application is concerned. Thank you.

Kathy

quote:

Originally posted by KathyC:

It is alkaline, so I am applying it to clean skin and waiting 30 minutes before applying anything else to get the best bang for my buck! Where are you putting it in your routine?

Kathy

Hi Kathy. I am also applying it to clean skin and waiting 30 minutes before applying anything else.

quote:

Originally posted by Dr. Pickart:
It will be a little like CP Serum but with the SRCPs replaced with DMAE.

Thank you. I have the same question as Kathy regarding the ph.