Hi, I'm new here, and have been surfing the forum for a while now. This is my first post. I have been using Skin Bio copper peptides for a few weeks, and am encouraged, but haven't seen a big improvement. I have been experimenting on my hands with a homemade resveratrol cream, and am amazed at the difference. However, when I use it on my face, I see no improvement. Dr. Pickart, does resveratrol conflict with copper peptides? I remember somewhere that you said that antioxidants alone cannot rebuild skin, and I have some major wrinkles. (and scars.) I have been using the copper peptides and resveratrol separately, at different times of the day. Should I discontinue the resveratrol? I am also taking it internally, and am astounded that most of my skin tags have fallen off. I've only been on it for a month.

Stony, I saw a picture of you, and cannot believe you have been married for 27 years. You looked younger than 27!

You can use Resveratrol and Copper peptides together.

The latest ideas on aging from the research area are that aging is caused by:

1. A lack of regenerative signals. This is the major cause.
2. Tissue oxidation. This was previously thought to be the major cause of aging.
3. An inflammatory state that occurs as we get older. Some call the "Metabolic Syndrome".
4. For the skin the excessive exposure to sunlight increases skin damage. But children's skin quickly repairs sun damage.

Copper peptides, which are generated during tissue breakdown and always exist in human blood, may be the key in the lack of organ repair that occurs with aging.

The following is from many published articles.

Biological Actions of Skin Remodeling Copper Peptides

In Vivo Actions
Improves aged skin (increases collagen, tightens skin, improves elasticity and firmness, reduces fine lines, wrinkles, photodamage, and hyperpigmentation), stimulates wound healing in numerous animal models and in humans, improves human hair growth and hair transplant success, protects and repairs gastric and intestinal lining, accelerates bone repair, increases infection resistance.

Cellular Actions
Increases the proliferation of fibroblasts, keratinocytes, chondrocytes, osteoblasts; increases nerve outgrowth, blood vessel angiogenesis, density of subcutaneous fat cells, and hair follicle size, increase PCNA (proliferating cell nuclear antigen), GHK increases stem cell proliferation. GHK-Cu increases stem cell differentiation into specific cell types and increase marker P63 (an indicator of stem cell activity)

Biochemical Actions
Attracts healing cells (capillary cells, macrophages, mast cells), increases synthesis of collagen, elastin, metalloproteinases, anti-proteases (with the overall effect to reduce protein breakdown), vascular endothelial growth factor, fibroblast growth factor 2, nerve growth factor, neutrotropins 3 and 4, erythropoietin; lowers blood pressure by inducing vasodilation of blood vessels.

Anti-inflammatory Actions
Increases anti-inflammatory proteins (superoxide dismutase, decorin), blocks the release of oxidizing iron from ferritin, suppresses inflammatory cytokines (transforming growth factor beta-1, tumor necrosis factor alpha, interleukin 1), blocks cellular damage by oxygen free radicals and reactive carbonyl species, reduces protein glycation, improves fibroblast recovery after X-ray treatments, blocks ultraviolet damage to skin keratinocytes, increases and reduces thromboxane formation, protects hepatic tissue from tetrachloromethane poisoning, inhibits protein glycation.

Thanks for your input, Dr. Pickart. Makes me want to find a copper peptide supplement for internal "remodeling."

Thanks Miss M...

Actually, I forgot to mention that I was in Kindergarten & my husband in the 7th grade when I got married. My teachers name was Miss Meredith...you're not her, are you???

I get my resveratrol in my "diluted red wine" , but MAY start taking it as a supplement too. What kind of cream have you made to use on your hands? My hands actually do give away my age... ... The veins are very close to the surface & since they are always into something (flour, water, dirt, paint, etc.) they are always pumped up. They look the best when I first wake up in the AM.

I apply CPs everywhere on my body, but it is my face that concerns me the MOST. Dr. Pickart's CPs are "true remodelers" and have been the answer to my prayers. I do NEED to concentrate a little more on my hands though, as they are the dead give away to ones real age.

Good Luck!

Lol! No, I am not Miss Meredith. MissM is Actually Miss Em, for Emilie.

It's interesting, my veins are very prominent also, but only on my left hand. (I am left handed.) I made my own cream, with about 1 1/2 ounces of cetaphil moisturizer, and 500mg of resveratrol. It has to be the white res, which is more pure, not the green capsules. It takes a while for the res to dissolve, maybe a day or so. If you use it before that, it is grainy. (This formula could change in the future.) My hand wrinkles are lessening, and there is a huge age spot that has almost disappeared. I just made some for my mother, who has a squamous cell melanoma on her leg that keeps returning after being cut off. I will be very interested to see how that works. I actually put 2 500 mg. capsules in hers.

Thanks for the recipe MissM,

I just MAY try & use in conjunction with my CPs. The CPs should help thicken the skin & make the veins less noticeable, but since my skin has always been thin on the back of my hands, the veins will probably always be noticeable.

Always being slender, I guess the concept of putting some meat on your bones would plump up the hands too, but I'd rather have veiny hands & be slender. Besides people in general rarely notice hands unless they are rough....and there is NO chance of having rough hands when using CPs & Emu Oil on your face...

Actually, My husband who is always putting his 2 cents in says "try washing your face in red wine... ...the people who stomp the grapes have feet as smooth as a baby's bottom"... ...I will NOT repeat what he said after that!

If I had the money, I'd get fat injections into the backs of my hands. I had old lady hands even when I was a teenager. There isn't one fat cell in there!

Stoney, the concept of gaining weight just to smooth out your hands just doesn't work. I'm glad you have rejected that idea. I am somewhat overweight, yet my hands look like an 80 year old's. SoftSkin, I had old lady hands at a very young age as well. I think that no matter what I do, the veins will always be prominent. I would just settle for some of the wrinkles disappearing.

Stoney, your husband's idea has some merit, but I think it is probably too expensive. (Unless you buy your wine at Trader Joe's for $1.99 a bottle.) Don't even know if you have them back East....