From what I've read, the copper peptides seem to replicate all the benefits, or promised benefits, of the latest cutting edge skincare. I was surprised to see it even affected stem cell production. I had purchased a special serum which uses apple stem cells to activate human ones.

Here's what the cosmetic chemists have accomplished with their sirtuin activation work.

"They found “1) significantly increased SIRT1 expression in normal human dermal skin fibroblasts in vitro (+172%) and in epidermal cells of healthy human skin ex vivo and 2) decreased cell senescence and DNA fragmentation induced by ultraviolet-B (UVB) stress.”

Do copper peptides (either generation) also promote sirtuin activity and let skin cells live longer.

If so, isn't aggressive exfoliation directly at odds with this as it promotes a more rapid turnover of cells?

It looks like gly-his-lys:copper 2+, the anti-aging copper peptide in your blood, is way ahead of the sirtuins.

From Wikipedia
Silent Information Regulator Two (Sir2) proteins, or sirtuins, are a class of proteins which possess either histone deacetylase or mono-ribosyltransferase activity and are found in organisms ranging from bacteria to humans.[2][3] Named after the yeast silent mating type information regulation two,[4] the gene responsible for cellular regulation in yeast, sirtuins regulate important biological pathways in eubacteria, archaea and eukaryotes.

Sirtuins have been implicated in influencing aging and regulating transcription, apoptosis and stress resistance.

...........

The problem is that the best known sirtuin, resveratrol, does not extend the lifespan in mice. It would also take 5 grams of resveratrol a day to have actions in humans. In contrast, GHK-Copper should act in humans at about 75 milligrams per day.

GHK-Copper has been demonstrated, in numerous studies, to reverse aging effects in the skin of women in their 50s. There are no lifespan studies but GHK was used in a cell culture system that grew thyroid cells for over 200 generations without becoming senescent.

The primary cause of aging is a decline in organ function over time. Up until we reach age 20, tissue and organs are maintained in a fully functional and healthy state. But as we age, repair slows and our organs fail to fulfill their biological role. Adult stem cells in organs create new cells for repair and the key protein in activating and supporting stem cell function appears to be protein P63. Without adequate P63, skin ages rapidly as do other tissue of the body.

Recent studies revealed that older animals have as many adult stem cells in their bodies as young animals. However, these stem cells are not differentiated into the types of cells needed to rejuvenate older tissue.

GHK-Copper increases protein P63 which activate epithelial (adult) stem cells, in addition to all of GHK-Copper's other protective and repair functions. Activation of these stem cells slows aging throughout the skin and body by rebuilding older tissues.

From my previous studies, we know the amount of GHK-Copper needed to activate strong systemic healing of skin throughout the body in mice, rats, and pigs. This should be the same as that needed to increase P63 and activate epithelial stem cells since wound healing proceeds via stem cell actions. GHK-Copper must also activate other types of adult stem cells since it has strong healing actions on on the stomach, intestinal linings and bone tissue. Approximately, 75 milligrams of GHK-Copper injected three times a week should be sufficient to activate human stem cells and improve the function of organs in older individuals. It is possible that GHK-Copper might be effective as an oral supplement enclosed in special liposomes that are taken up by the lymphatic system to avoid possible breakdown by intestinal enzymes.

The 75 milligram level of GHK-Copper should be very safe and is 280-fold below expected negative actions of the molecule caused by its blood pressure lowering actions.

GHK-Copper, with its stem activation plus regenerative, anti-inflammatory, and anti-infection properties, may be the best biochemical candidate for the "Fountain of Youth" biochemical.

For more on this, go to http://reverseskinaging.com/GH...untain_of_Youth.html

This message has been edited. Last edited by: Dr. Pickart,

Thank you for your well considered answer. It's nice to know that whatever the cosmetic chemists are cooking up as the latest and greated in skincare, your products already do.

The question is though, if the cosmetics companies are aware of this, then why are they spending millions in aging research to reinvent the wheel?

I have been offered some very good positions in large cosmetic companies, but decided to keep my freedom to think, talk, and published my ideas.

The large cosmetic companies are essentially advertising agencies that sell skin and hair products. They are trapped. They sell products that need instant results at a cosmetic counter. To make skin look better, the products are formulated to break the skin barrier and push water into the skin and swell the skin like a balloon to make lines and wrinkles less obvious. They also use wetting agents to make the outer skin layer wet (hydrating) plus using dyes and optical diffusers to give the outer skin a younger look. Some use peptides that act like TGF-beta-1, the scar forming protein. These peptides create hard protein in the skin but do not remove older proteins and buried skin damage.

This short term beauty enhancement is offset by the long-term damage caused by such methods. Keeping the outer skin wet inhibits the flow of keratinocytes to the outer skin. Damaging the skin barrier lets bacteria and viruses enter the skin more easily and this causes more spots and bumps to develop in on the skin. Chemical dyes have a long reputation for damaging skin and other tissues and many types of dyes have been banned in the past.

Finally, there is very little serious skin research by the academic community. Too many academics are heavily compensated by the cosmetic companies and avoid basic skin research but publish endless trivia.